Catatan Seorang Farmasis

Posts Tagged ‘Penyakit rematik dan Pengobatannya


By : fh4djh4r

Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response provides the most comprehensive body of knowledge available on the role of genetic and genomic variation in the individualization of drug therapies in cancer patients. As a consequence of the intrinsic chromosomal and genetic instability of the tumor genome, it is generally believed that tailoring of chemotherapy in cancer patients might be achieved by molecular analysis of patient tumor DNA. In addition, to reduce the toxicity risk of patients, the tumor DNA information should be integrated with the available data on polymorphic drug-metabolizing enzyme and transporter genes mediating the exposure of patients to active drugs and/or their active metabolites. The chapters of this book clearly show how DNA information from both the host (germline) and the tumor should be taken into account for rational selection of drug therapies in cancer patients, an aspect that received little attention, despite its importance.

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By : fh4djh4r
During the last decades, investigation into rheumatoid arthritis has benefited from the enormous growth in understanding principal functions of the immune system and the explosion in the knowledge of molecules involved in regulating normal and pathologic immune responses. Despite this progress, the disease has defied a unifying concept and new challenges and perspectives have emerged. Once again, it is becoming evident that research of autoimmune diseases is not a one-way street but a dialectic process between basic science and disease studies. We have learned that rheumatoid arthritis is not a single mechanism-single molecule-single gene disease. The chapters commissioned in this volume illustrate the many facets of disease pathogenesis.

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