Catatan Seorang Farmasis

Oxidative stress and disease

Posted on: 06/19/2011


By : fh4djh4r

Oxidative stress is a major factor in health, aging, and disease and is often defined by the redox balance established by cellular oxidants and antioxidants. The ratio of reduced to oxidized levels of major low-molecular weight protein thiols, such as cysteine and glutathione or thioredoxin and glutaredoxin, is often used as a measure of oxidative stress. Among naturally occurring thiols, the discovery of a-lipoic acid has led to an unprecedented interest in basic research because of its role in energy metabolism and as an antioxidant for the treatment of certain
diseases. a-Lipoic acid has acquired importance because of its role as a coenzyme in the maintenance of energy metabolism, on one hand, and as an antioxidant and cell redox modulator, on the other hand. The former was supported by the discovery of the essential role of lipoic acid in mitochondrial dehydrogenasedriven reactions inherent in energy metabolism and the latter is supported by reduction of supplemental a-lipoic acid to dihydrolipoic acid in mammalian cells conferring further antioxidant protection. For example, lipoic acid is an essential cofactor of a-keto acid dehydrogenase complexes in eukaryotic cells as part of the lipoyl domain of the E2 enzymes (dihydrolipoamide acyltransferases). Also, exogenous R- (or RS)-lipoic acid is reduced by a flavoenzyme, dihydrolipoamide dehydrogenase, of the complex in mitochondria. Hence lipoic acid may be a mitochondrial-targeted nutrient. The cell redox status is a critical factor regulating cell proliferation, differentiation, apoptosis (programmed cell death), and necrosis, and the mitochondrion is a center of interest for its role in the generation of signaling molecules (e.g., hydrogen peroxide and nitric oxide) that, in turn, modulates the redox status of the cell.

This ebook can be download at:

Download In Here

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

Page Translate


Klik tombol di bawah ini untuk berlangganan ke blog saya dan menerima pemberitahuan posting baru melalui email.

Join 11 other followers

Me Inside

want to be friends with you

All Articles

RSS Lintas Olahraga

  • An error has occurred; the feed is probably down. Try again later.

RSS Seputar Enterpreneur

  • An error has occurred; the feed is probably down. Try again later.

See All My Tag

Antibakteri asam salisilat belajar wordpress bagi pemula Buku Pegangan farmasetika cara buat avatar cara buat buku tamu hanya dalam hitungan menit cara memasang emoticon diblog Cara memformulasikan sediaan suspensi cara mengatasi sakit haid cara menyembuhkan herpes simplex Cara menyembuhkan Penyakit Hipertensi cara pasang avatar ciri ciri keguguran ciri ciri orang hamil daftar isi bagi pemula wordpress Diagnosa Kanker Dan patofisiologi Kanker Disfungsi Ereksi dosis albendazle dosis aspirin efek samping aminofilin efek samping amoksisilin EKSTRAK DAUN JAMBU BIJI farmakologi obat herbal di negara china Formulasi Bahan Kosmetika HomePage Kaskus Infeksi saluran kemih ISK Istilah kaskus kala I II III IV Kasih Ibu Sepanjang Masa kebutuhan bayi terhadap gizi yang seimbang Kedisiplinan adalah Kunci dari keberhasilan keluarga berencana Keutamaan Shalat Subuh dan Ashar macam macam penyakit haid Manfaat mengikuti program KB Mekanisme albendazole mekanisme aminofilin mekanisme amoksisilin mekanisme dan dosis asiklovir mekanisme haid mekanisme kerja asetosal Mekanisme Tabir surya Minyak atsiri Motivasi Mario teguh tentang rejeki nyeri datang bulan obat antibiotik untuk sakit gigi obat sakit asma Penanganan gizi buruk pengobatan infeksi cacing pentingnya ber KB pentingnya gizi seimbang untuk bayi penting nya jiwa kepemimpinan Penyakit rematik dan Pengobatannya penyembuhan infeksi aluran kemih perkembangan KB proses persalinan Rahasia Amanah Registrasi Kaskus Rule of the Kaskus script Html bagi pemula Scrolldown yang menarik Sejarah Farmasi Sejarah KasKus seputar informasi KB Sesepuh Kaskus siapakah ahli sunah itu? Staphylococus. Stres Dan Penyebabnya Sukses Wawancara tahapan persalinan pada ibu hamil tanda tanda kehamilan Tips Mudah meningkatkan PR dan banyaknya blacklink toxicology the basic science of poisons Tutorial Wordpress terlengkap

TooLs

Pengunjung Saat Ini Dari

Polling Blog Me